KMID : 1059519980420040449
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Journal of the Korean Chemical Society 1998 Volume.42 No. 4 p.449 ~ p.453
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Synthesis of 4H-1,3,4-Oxadiazino[5,6-b]quinoxaline Derivatives
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Kim Tong-Eun
Kim Ho-Sik
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Abstract
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The reaction of 6-chloro-2-hydrazinoquinoxaline 4-oxide (11) with ethyl chloroglyoxylate provided ethyl 8-chloro-4H-1,3,4-oxadiazino[5,6-b]quinoxaline-2-carboxylate (12) through the intramolecular cyclization. The reaction of 12 with hydrazine hydrate afforded the C2-hydrazinocarbonyl derivative 13, whose reactions with substituted benzaldehydes or heteroaryl aldehydes provided 8-chloro-2-(substituted benzylidenehydrazinocarbonyl)-4H-1,3,4-oxadiazino[5,6-b]quinoxalines (14) or 8-chloro-2-[(2-substituted methylidene)hydrazinocarbonyl]-4H-1,3,4-oxadiazino[5,6-b]quinoxalines(15), respectively.
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KEYWORD
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